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Lemborexant

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Lemborexant

E2006
CAS Number: 1369764-02-2
Chemical Name: (1R, 2S) -2 – {[(2,4-dimethylpyrimidin-5-yl) oxy] methyl} -2- (3-fluorophenyl ) N (5-fluoropyridin-2-yl) cyclopropanecarboxamide
Indication: Insomnia
Company: Eisai

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Lemborexant (INN) (code name E-2006) is a dual antagonist of the orexinOX1 and OX2receptors which is under development byEisai for the treatment of insomnia.[1][2][3] As of December 2014, it is in phase IIclinical trials.[4]

Synthesis coming…….watch out

References

  1. Christopher, John A (2014). “Small-molecule antagonists of the orexin receptors”. Pharmaceutical Patent Analyst 3 (6): 625–638.doi:10.4155/ppa.14.46. ISSN 2046-8954.
  2. Cristoph Boss, Catherine Ross (2015). “Recent Trends in Orexin Research – 2010 to 2015”. ScienceDirect.doi:10.1016/j.bmcl.2015.05.012.
  3. Boss, Christoph (2014). “Orexin receptor antagonists – a patent review (2010 to August 2014)”. Expert Opinion on Therapeutic Patents 24 (12): 1367–1381.doi:10.1517/13543776.2014.978859. ISSN 1354-3776.
  4. AdisInsight. “Lemborexant”. Springer. Retrieved 2015-05-23.

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Lemborexant
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Systematic (IUPAC) name
(1R,2S)-2-[(2,4-dimethylpyrimidin-5-yl)oxymethyl]-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl)cyclopropane-1-carboxamide
Clinical data
Legal status
  • experimental drug
Identifiers
CAS Registry Number 1369764-02-2
ATC code None
PubChem CID: 56944144
ChemSpider 34500836
Chemical data
Formula C22H20F2N4O2
Molecular mass 410.417 g/mol

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