Solubility Advantage of Amorphous Drugs and Pharmaceutical Cocrystals

Hi everyone, I thought I might begin this week talking about crystallizations.  One of the most popular postings I had on my website was one on polymorphs.   Although this week’s pick or review is not on polymorphs, it is a burgeoning area of study in the crystallization field.  I am talking about the use of co-crystals in active pharmaceutical ingredient crystallizations.  This is definitely something I don’t know too much about, but feel that is of great importance.  I have done a few crystallizations and wanted to steer clear of amorphous drugs.  In fact, a few of the projects that I have worked on, the product was not crystalline.  One of them had to spray-dried as a mesylate salt.  Adding another compound into the mix didn’t seem like a solution at the time, but who am I to know ?  Would you have considered it ?

So I was intrigued when I came across…