I.R. Baxendale, S.C. Schou, J. Sedelmeier, S.V. Ley, Chem. Eur. J. 2010, 16, 89-94.
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http://onlinelibrary.wiley.com/doi/10.1002/chem.200902906/abstract
Multi-step in flow: The palladium-catalysed acylation of terminal alkynes for the synthesis of yne![[BOND]](http://onlinelibrarystatic.wiley.com/undisplayable_characters/00f8ff.gif)
ones as well as their further transformation to various heterocycles in a continuous-flow mode is presented. Furthermore, an extension of the simple flow configuration that allows for easy batch splitting and the generation of a heterocyclic library is described (see scheme).
Filed under: organic chemistry Tagged: flow reactors, FLOW SYNTHESIS, J. Sedelmeier, S.C. Schou
