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ND 2158
(2S)-2-hydroxy-3-[(3R)-12-{[(1r,4r)-4-(morpholin-4-yl)cyclohexyl]oxy}-7-thia-9,11-diazatricyclo[6.4.0.0²,⁶]dodeca-1(12),2(6),8,10-tetraen-3-yl]propanamide...
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Curis and Aurigene’s AUPM 170, CA 170
1,2,4-oxadiazole and 1 ,2,4-thiadiazole compounds of formula (I): ONE EXAMPLE OR 1,3,4-oxadiazole and 1 ,3,4-thiadiazole compounds of formula (I): EXAMPLES PREDICTED AUPM 170, CA 170, AUPM-170, CA-170...
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Curis and Aurigene’s CA 4948, AU 4948
Example 13 WO2015104688 6-(6-aminopyridin-3-yl)-N-(2-morpholin-4-yl-1,3-benzothiazol-6-yl)pyridine-2-carboxamide Molecular Formula: C22H20N6O2S Molecular Weight: 432.4982 g/mol 1428335-77-6...
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FDA approves new drug Venclexta (venetoclax) for chronic lymphocytic leukemia...
Venclexta (venetoclax) SYNTHESIS...
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Zamicastat
CAS 1080028-80-3 BASE 1383828-47-4 OF HCL SALT C21 H21 F2 N3 O S BASE 2H-Imidazole-2-thione, 1-[(3R)-6,8-difluoro-3,4-dihydro-2H–...
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ETAMICASTAT
Etamicastat HCl salt CAS: 677773-32-9 (HCl salt) CAS 760173-05-5 (free base). Chemical Formula: C14H16ClF2N3OS Molecular Weight: 347.8088 Synonym: BIA 5-453; BIA5-453; BIA-5-453; Etamicastat...
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PF-05387552
PF-05387552 IRAK4 CAS 1604034-71-0 C25 H27 N5 O2 11H-Indolo[3,2-c]quinoline-9-carbonitrile, 2-methoxy-3-[3-(4-methyl-1-piperazinyl)propoxy]-...
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Asvasiran sodium (ALN-RSV01)
RNA, (C-U-U-G-A-C-U-U-U-G-C-U-A-A-G-A-G-C-C-DT-DT), COMPLEX WITH RNA (G-G-C-U-C-U-U-A-G-C-A-A-A-G-U-C-A-A-G-DT-DT) Duplex of...
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GSK-525762A
GSK 525762A; 1260907-17-2; I-BET-762; GSK525762A; UNII-5QIO6SRZ2R; 5QIO6SRZ2R; CAS1260907-17-2...
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TAK-058 (ENV-8058)
TAK-058 , ENV-8058 5-HT 3 receptor antagonist Envoy Therapeutics, Inc. 1-(1-methyl-1H-pyrazol-4-yl)-N-((1R,5S,7S)-9-methyl-3-oxa-9-azabicyclo[3.3.1]nonan-7-yl)-1H-indole-3-carboxamide...
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Henagliflozin
Henagliflozin, SHR-3824 , CAS 1623804-44-3 C22-H24-Cl-F-O7 454.8756 PHASE 2 for the treatment of type 2 diabetes HengRui (Originator) Jiangsu Hengrui Medicine Co Ltd UNII-21P2M98388; 21P2M98388;...
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ATR 101
N-(2,6-bis(1-methylethyl)phenyl)-N’-((1-(4-(dimethylamino)phenyl)cyclopentyl) methyl)urea hydrochloride N-(2,6-BIS(l-METHYLETHYL)PHENYL)-N’-((l-(4- (DIMETHYLAMINO)PHENYL)CYCLOPENTYL)METHYL)UREA...
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INCB24360 (epacadostat)
Epacadostat (Z)-N-(3-bromo-4-fluorophenyl)-N’-hydroxy-4-[2-(sulfamoylamino)ethylamino]-1,2,5-oxadiazole-3-carboxamidine 1,2,5-Oxadiazole-3-carboximidamide,...
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AMG 337
. PIC CREDIT.BETHANY HALFORD Name: AMG-337(AMG337; AMG 337) Cas 1173699-31-4 Formula: C23H22FN7O3 M.Wt: 463.46 Chemical Name:...
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ND 0126
ND 0126 CAS 1240322-54-6 Molecular Formula: C29H25F3N6O3 Molecular Weight: 562.54241 g/mol methyl...
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PF-06260414
PF-06260414 CAS: 1612755-71-1 Chemical Formula: C14H14N4O2S Exact Mass: 302.0837 PF-06260414; PF 06260414; PF06260414; PF6260414; PF-6260414; PF 6260414. IUPAC/Chemical Name:...
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ORVEPITANT
Molecular Formula: C31H35F7N4O2 Molecular Weight: 628.624022 g/mol CAS 579475-18-6 Orvepitant (GW823296)...
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Enasidenib (AG-221)
Enasidenib (AG-221) 1446502-11-9 Chemical Formula: C19H17F6N7O Exact Mass: 473.13988 AG-221; AG 221; AG221; CC-90007; CC 90007; CC90007; Enasidenib IUPAC/Chemical Name:...
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Regulatory Approval Pathways: EU vs US
DRUG REGULATORY AFFAIRS INTERNATIONAL Regulatory Approval Pathways: EU vs US Drug Authorization Procedures in the EU Sponsors have several options when seeking market approval for a new drug in...
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