Sep 17, 2014,
Under terms of the agreement, Sun Pharma will acquire worldwide rights to tildrakizumab for use in all human indications from Merck in exchange for an upfront payment of USD 80 million.
Pharma major Sun Pharmaceutical Industries today entered into a licensing agreement with Merck & Co Inc for investigational therapeutic antibody candidate, tildrakizumab to be used for treatment of plaque psoriasis. Under terms of the agreement, Sun Pharma will acquire worldwide rights to tildrakizumab for use in all human indications from Merck in exchange for an upfront payment of USD 80 million, the companies said in a joint statement. Tildrakizumab is being evaluated in Phase III registration trials for the treatment of chronic plaque psoriasis, a skin ailment. “Merck will continue all clinical development and regulatory activities, which will be funded by Sun Pharma. Upon product approval, Sun Pharma will be responsible for regulatory activities, including subsequent submissions, pharmacovigilance, post approval studies, manufacturing and commercialisation of the approved product,” it added.
Sun Pharma managing director Dilip Shanghvi.
| Monoclonal antibody | |
|---|---|
| Source | Humanized (from mouse) |
| Target | IL23 |
| Clinical data | |
| Legal status |
?
|
| Identifiers | |
| CAS number | 1326244-10-3 |
| ATC code | None |
| Chemical data | |
| Formula | C6426H9918N1698O2000S46 |
| Mol. mass | 144.4 kDa |
Tildrakizumab is a monoclonal antibody designed for the treatment of immunologically mediated inflammatory disorders.[1]
Tildrakizumab was designed to block interleukin-23, a cytokine that plays an important role in managing the immune system andautoimmune disease. Originally developed by Schering-Plough, this drug is now part of Merck‘s clinical program, following that company’s acquisition of Schering-Plough.
As of March 2014, the drug was in phase III clinical trials for plaque psoriasis. The two trials will enroll a total of nearly 2000 patients, and preliminary results are expected in June, 2015. [2][3]
References
- Statement On A Nonproprietary Name Adopted By The USAN Council – Tildrakizumab, American Medical Association.
- http://clinicaltrials.gov/ct2/show/NCT01729754?term=SCH-900222&phase=2&fund=2&rank=1
- http://clinicaltrials.gov/ct2/show/NCT01722331?term=SCH-900222&phase=2&fund=2&rank=2
Filed under: ANTIBODIES, Monoclonal antibody Tagged: MERCK, Monoclonal Antibodies, Monoclonal antibody, sun pharma, Tildrakizumab
